ALS: What you should know about the incurable, debilitating disease(2023)

ALS:- According to a statement from family members, Bryan Randall died following a three-year battle with the disease and chose early on to keep the battle private.

“Those of us who cared for him did our best to honor his request,” read a portion of the statement.

Here’s what you should know about the disease.

Bryan Randall died cause of als

What is ALS?

According to the website of Johns Hopkins Medicine, which stands for “Amyotrophic Lateral Sclerosis,” is a disease that is characterized by progressive degeneration of nerve cells in the spinal cord and brain.

According to Mayo Clinic’s website, this affects motor neurons, or nerve cells that control voluntary muscle movements, like walking and talking.

“This causes both groups of motor neurons to gradually deteriorate and then die. When motor neurons are damaged, they stop sending messages to the muscles. As a result, the muscles can’t function,” read a portion of Mayo Clinic’s website.

Ths is considered to be a common form of motor neuron diseases, according to the National Institute of Neurological Disorders and Stroke.

The disease, according to the website, is often called Lou Gehrig’s Disease. According to his entry in the Encyclopedia Britannica, Lou Gehrig was a professional U.S. baseball player who was diagnosed with the disease in 1939 and died in 1941.

What causes ALS?

According to Johns Hopkins Medicine’s website, experts do not know the cause of this.

On the Mayo Clinic’s website for ALS, it is stated that for about 10% of people with ALS, a genetic cause can be identified.

“Most theories center on a complex interaction between genes and factors in the environment,” read a portion of the Mayo Clinic’s website on ALS.

According to the Mayo Clinic’s website, there are some established risk factors for ALS, such as:

  • Age, with ALS being most common between the ages of 60 and the mid-80s.
  • Gender, with slightly more men than women developing ALS before the age of 65. The gender-based difference, however, disappears after the age of 70.

Other environmental factors have also been associated with an increased risk for ALS, according to the Mayo Clinic, such as smoking, environmental toxin exposure, and military service.

“It’s not clear what about military service might trigger ALS. It might include exposure to certain metals or chemicals, traumatic injuries, viral infections, or intense exertion,” read a portion of the Mayo Clinic website.

According to Johns Hopkins Medicine’s website, is not contagious, meaning it can’t spread from person to person like the cold or the flu.

What are the symptoms of this disease?

According to the website of Johns Hopkins Medicine, people with this may first have weakness in a limb that develops over a matter of days or weeks.

“Then, several weeks to months later, weakness develops in another limb. Sometimes the initial problem can be one of slurred speech or trouble swallowing,” read a portion of the website.

More symptoms, according to the website, may be noticed as this disease progresses. The symptoms include:

  • Muscle twitching and cramping, especially those in the hands and feet
  • Loss of hands and arms motor control
  • Impairment in the use of arms and legs
  • Tripping and falling
  • Dropping things
  • Persistent fatigue
  • Uncontrollable periods of laughing and crying

The website states trouble breathing, trouble swallowing and paralysis are also symptoms in the later stages of the disease.

According to the Mayo Clinic, some people with AMS may eventually be diagnosed with a form of dementia called frontotemporal dementia.

How can someone be diagnosed with this?

According to the Cleveland Clinic’s website, a healthcare provider will do a physical exam, and ask a person about their medical history. Several other theses will also be done to confirm an ALS diagnosis, including

  • Blood and urine tests
  • A neurological examination
  • Electromyogram, or a test to measure the electrical activity of a person’s nerves and muscles
  • A nerve conduction study to test nerves’ ability to send a signal
  • MRI to look at a person’s brain or spine for areas of damage

Other tests may also be done to rule out different diseases with similar symptoms, including spinal fluid tests and muscle and/or nerve biopsy.

Can this be cured?

According to the websites of Cleveland Clinic and Johns Hopkins Medicine, there is no cure.

Are there treatments for this?

According to the Cleveland Clinic’s website, treatments can slow the progression of this disease, and they could include the following:

  • Medicine
  • Physical therapy
  • Nutritional counseling
  • Speech therapy
  • Assistive devices and special equipment, including wheelchairs and electric beds

According to the Cleveland Clinic’s website, also choose to do what is known as “voice banking,” or the act of recording a person’s voice in a speech synthesizer, which will allow a person to communicate via the speech synthesizer if they can’t speak later on.

On the Mayo Clinic’s website, it is stated that the Food and Drug Administration has approved three medicines for the treatment of this disease, including:

  • Riluzole
  • Edaravone
  • Sodium Phenylbutyrate-taurursodiol, also known as Relyvrio.

Treatments, according to the Mayo Clinic’s website, cannot reverse the damage caused by this disease.

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